The future of U.S. vaccine policy is uncertain and fragmented following the end of the federal public health emergency. The article explores the current landscape, where authority has largely shifted back to states, employers, and schools, leading to a patchwork of varying requirements and recommendations. Key challenges include navigating evolving scientific guidance on booster shots, addressing vaccine hesitancy, and determining the role of mandates in workplaces and educational institutions. Public health officials and policymakers are grappling with how to maintain high vaccination rates against COVID-19 and other diseases without the centralized coordination of the pandemic’s peak. The path forward remains unclear as the nation transitions from emergency response to long-term management of endemic disease. Read the full article at: https://www.wired.com/story/no-one-knows-where-us-vaccine-policy-goes-next/